1109 North Walnut Avenue, New Braunfels, Texas 78130, United States
Weight Loss
There are two popular weight loss peptides that most have heard of, Semaglutide and Tirzepatide.
What exactly do they do and what makes them different?
Both Semaglutide and Tirzepatide mimic peptide hormones found in the gut called Incretins, which stimulate insulin production after eating. The two main Incretins are Glucagon Like Peptide 1 (GLP-1) and Glucose Dependent Insulinotropic Peptide (GIP).
Semaglutide is a GLP-1 agonist. This means it mimics one of the incretins (GLP-1) and is responsible for increased insulin production, improved gut motility and it suppresses your appetite.
Tirzepatide is a dual agonist and mimics both GLP-1 and GIP Incretins. It does everything Semglutide does, but also stimulates lipolysis (fat metabolism).
Both peptides have shown significant weight loss results in both phase 3 trials and in real world evidence, with Tirzepatide showing a greater % of overall weight loss. Tirzepatide also tends to have less stomach discomfort and nausea that can sometimes be reported with semaglutide.
Who is a good candidate for these prescriptions?
An ideal candidate has a BMI of 30 or greater and has tried calorie deficit diets and exercise without success in losing weight.
What are the benefits?
Tirzepatide, marketed as Mounjaro for type 2 diabetes and Zepbound for weight loss, has several benefits, including:
- Weight Loss*: Tirzepatide is known for its ability to reduce weight, especially in people with type 2 diabetes. Studies have shown that it can help people lose an average of 27% of their body weight over the course of a year and a half when combined with diet and exercise.
- Reducing Blood Sugar Levels*: Tirzepatide decreases blood sugar levels by increasing insulin production and lowering the amount of sugar the liver makes.
- Reducing Appetite*: Tirzepatide works for weight loss by decreasing appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period of time.
- Lowering Blood Pressure*: Tirzepatide can reduce blood pressure by more than 7.4 mm Hg, according to a new study. The study only included people who have normal blood pressure, so it’s unclear what the effect will be in people with uncontrolled hypertension.
- Improving Cholesterol Levels*: Tirzepatide has been shown to improve cholesterol levels in patients who take it.
- Reducing Fat Mass*: Tirzepatide achieved significant weight reduction versus placebo in people with type 2 diabetes. Body composition analyses demonstrated that the body weight loss was mainly due to fat mass reduction.
Schedule an Appointment
Give Mandy a call to discuss if Semaglutide or Tirzepatide are right for you.